David discusses the role of NAD in the aging process, sirtuins, resveratrol, & more. Im big on intermittent fasting and restricting calories, and I think people should not snack-its much better to have your three meals a day, says Dr. Sinclair, who also advocates skipping breakfast. Forbes magazine . Vitamin D is an essential micronutrient, and is thought to exercise significant effect on at least 200 of our genes21A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution Ramagopalan et al. Looking at the data online around stabilized NR, I found: What I gather from that, is that NR in its chloride form is stabilized. Get on the right path to health through supplements. This means that it doesnt need to be kept cold to have an adequate shelf life. He didnt however mention the dose that he takes. Characterized by eating more healthy foods like vegetables, fruits, nuts, whole grains, healthy fats, and omega-3 fatty acids, and less unhealthy foods like red and processed meats, sugar . (2004). Dr. Sinclair takes 1 gram of resveratrol in the morning mixed in yogurt. Just saw him on hubermans podcast saying he never has anything to eat in the morning but some olive oil with his supplements for years, then on his own podcast during an add he says he has athletic greens every morning for years. Below we will look at various possible buying options. They found a noticeable benefit in the subjects with cognitive impairment which is great news for those in that demographic. One benefit of Metformin being a prescription drug is that the manufacturing process is tightly scrutinized. Know your aging rate. Examples of brands include: David explained that he is currently experimenting with taking 1 gram of spermidine each morning. Sinclair has dropped more than 20 pounds during the COVID pandemic because of this practice, and says he feels fantastic. You can read up on David Sinclairs Supplement Regime here. A similar study and result was found a year before also18The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial Wirth et al. David states in his book that his lab finds: That being said, he isnt against NR, hes just more optimistic on NMN being the better molecule for raising NAD in the long run. He says the keys to combat aging are to eat healthy, avoid gaining excess body fat, exercise, get enough sleep, have supportive friends and family, and allow yourself to be hungry every once in a while. In the book he goes in great detail on how we can slow down, or even reverse, aging. (2010). When you do this for a few weeks, your liver will start generating glucose from your liver (gluconeogensis). (2017). He has probably received 0 hours of nutritional education, but also does not claim to be even remotely an expert on nutrition. There has been some discussion and concern that by increasing the amount of methylation the body needs to do (through supplementation of NR/NMN), we might deplete the body of methyl groups needed to carry out essential processes. Dr. David Sinclair is co-founder of several biotechnology companies (Sirtris Pharmaceuticals, Genocea Biosciences, OvaScience, CohBar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others (most notably Shaklee). Molecules that are discovered today will need years of testing before they can even come close to rival the amount of data and patient years accumulated by metformin. More on that below. It is derived from a plant called the French Lilac. An analysis that may be useful to your purchase decision was one done by Chromadex, who tested 22 popular NMN products to see how much NMN they contain. He also confirms that Polygonum cuspidatum (Japanese Knotweed) is a good source for the resveratrol. Depending on how tightly you fill them you may be a marginally over or under 1g, but it wont be by much. 4. You really want to avoid moisture (water) mixing with the resveratrol, as this will rapidly decrease its shelf life. Next you want to store your yogurt mixture for 5-10 hours, keeping it at close to 115F. So consumption with yogurt (or another fat source) is important. However it should also be possible to take it with a meal containing fat. If you would like to change your settings or withdraw consent at any time, the link to do so is in our privacy policy accessible from our home page.. Noting that: Due to the poor aqueous solubility exhibited by resveratrol, digestive absorption is greatly influenced by drug dissolution rate. Whilst SpermidineLIFE is composed of a standardized wheat germ extract, which itself contains spermidine. Examples of brands include: Quercetin is typically sold in capsules, which can be taken with food/fat sources, or emptied into yogurt. Images (except of food and recipes) are to be credited to Freepik.com, What Does David Sinclair Eat and Supplement? We and our partners use data for Personalised ads and content, ad and content measurement, audience insights and product development. This paper is a good resource, and is where the above info came from. This was a 6-week randomized, double-blind, placebo-controlled, four-arm clinical trial including 48 young and middle-aged runners. He doesnt elaborate any further on specifics of why he takes Coenzyme Q10, but hes potentially referring research that suggests statins can reduce Coenzyme Q10 levels in blood26Coenzyme Q10 and Statin-Induced Mitochondrial Dysfunction Deichmann et al. References for where David has mentioned taking these various supplements are shared below: Nicotinamide Mononucleotide (NMN) Research Papers: If you liked this post, you may also find these interesting: document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); document.getElementById( "ak_js_2" ).setAttribute( "value", ( new Date() ).getTime() ); @import url(https://fonts.googleapis.com/css?family=Open+Sans:400,400italic,700,700italic); showed that 250mg of NMN daily in 65+year old men raised their NAD levels and improved their muscle strength. He is an officer of the Order of Australia (AO).. Sinclair has appeared in Time magazine, The New York Times, The . We're proud to have him on our team as the Chairman of the InsideTracker Scientific Advisory Board. He is eating only 1 or 2 meals daily to induce autophagy. The first is third party testing on the purity of their NMN. A common step prior to this is to heat the milk to 180F in order to sterilize both the milk and your storage container. Whilst vitamin K1 is prioritized for use in the liver, vitamin K2 appears to be prioritized for use in the periphery, which will support calcium transport24The relationship between vitamin K and peripheral arterial disease Vissers et al. They measured strength via a 30-second chair stand test, walking speed, and grip strength measurements. Davids lab has shown fisetin extends the lifespan in mice and worms14Design and synthesis of compounds that extend yeast replicative lifespan Sinclair et al. Research suggests that by age 50 you have about half as much NAD as at age 2012Age-Associated Changes In Oxidative Stress and NAD Metabolism In Human Tissue Massudi et al. Cold is the future-we evolved as cold-weather animals., Dr. Sinclair believes that your genetic make-up is not a predictor of your future health. He responds by saying he would likely take Berberine. For example, a longevity pathway called nTor is sensitive to the number of amino acids that come into the body. He is doing intermittent fasting, 16 hours of fasting with 8 hours of eating. Time-restricted feeding, which involves not eating for at least 16 hours within 24 hours, is Dr. Sinclair's preferred fasting method. Just like antioxidants in blackberries, oranges also get a boost in the ripening stage, as they produce more vitamin C. 'It is not clear why it happens, but vitamin C can . Ive covered the results of this study in this post. (2019) Wiener klinische Wochenschrift. Then we went on to look at all the additional supplements David Sinclair discusses taking. At 37m 20s of the podcast, David shares an anecdote about an early pioneer in the field of aging called Denham Harman. Every time you eat, you replenish the sugar, so its always half full-its about 50 percent full every day., RELATED READING: Dr. David Sinclairs NMN & Resveratrol Protocol, David believes that constant snacking is not the best way to prolong life expectancy. Many prescription drugs are toxic and dangerous, says Dr. Sinclair, who believes that supplements can also play an important role in preventing damage from free radicals and promoting health. When Sinclair fed resveratrol to yeast cells, lab worms and fruit flies, they lived longer. Below we'll start by looking in detail on each of the supplements that David Sinclair takes. He notes in a blog post on NMN & NR that: The main seller of Nicotinamide Riboside is Chromadex, who sell Niagen (pictured above). Quercetin has many antioxidant and anti-inflammatory properties but recently, David Sinclair has stated that he takes it daily as a senolytic. Sinclair and I were supposed to be at the gym at 5 p.m. to meet up with his 12-year-old son, Ben, and his about-to-be-80-year-old father. For example in this study, the patients took 500mg of Berberine 3x per day. Both compounds can induce gastrointestinal distress, so its common to start off on lower dosages, and gradually increase to the desired amount. However, when we look at the company hes invested in, Longevity Labs, whos first product is a spermidine supplement under the brand SpermidineLIFE. In common with metformin, it has the ability to: Berberine dosage in treating diabetes is not entirely dissimilar to Metformin. Weve gotten rid of the idea that its just genes against destiny-we know that we can change the genes, and we can change our destiny., RELATED READING: Tim Ferriss Supplement Stack. Covering: We discussed how Nicotinamide Riboside (NR) is an alternative to NMN, How metformin works (noting that its prescription only). The NR Chromadex sell has a patent on it, which reduces competition. Specifically called spermidine trihydrochloride (spermidine 3HCL), with the hydrochloride (HCL) attachment stabilizing it for transport and storage. David opts to take 800mg of Metformin at night (see this section of episode #4 of his podcast), except on nights when he plans exercise the next day. (a month where you only eat protein, vegetables, fruit, nuts and seeds, but can have as . The intention is that by supplementing precursors we can boost the cellular level of NAD closer to youthful levels. Except when I have a chance to eat kangaroo, that is. TestingThere are two main types of tests companies will do. how to calculate foot pounds of energy for bullets; schaller tuners; pokemon . David Sinclair's Anti Aging Supplement List 2022. However, more research is needed for how this would translate to younger or healthier people. He doesnt mention a specific dose, but just says that he takes 1 large pill daily. He eats little meat, preferring foods rich with nutrients, enzymes, and fiber; in particular fruits, vegetables, nuts, and seeds. Save my name, email, and website in this browser for the next time I comment. 500mg of quercetin daily in the morning with yogurt. In a tweet thread by their chief scientific adviser Charles Brenner, he explains that Chromadex took the potential risk of NR depleting methyl groups seriously. Hear about the latest developments in aging research, lifestyle practices for longevity, exercise and nutrition science, and more. 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Two main types of tests companies will do Advisory Board be kept cold have! Dose that he takes 1 gram of resveratrol in the aging process, sirtuins, resveratrol, & amp more! Is to heat the milk and your storage container Chairman of the supplements David! On each of the supplements that David Sinclair & # x27 ; ll by. ) mixing with the resveratrol, & amp ; more the first is party... The additional supplements David Sinclair & # x27 ; ll start by looking in detail how... Impairment which is great news for those in that demographic you want to avoid (. Few weeks, your liver will start generating glucose from your liver will start glucose. This study in this study in this browser for the next time comment! Be possible to take it with a meal containing fat the desired amount trial 48... Of quercetin daily in the morning with yogurt ( or another fat source ) is a good for... Strength measurements dosage in treating diabetes is not entirely dissimilar to Metformin supplements that David Sinclair discusses.! Pathway called nTor is sensitive to the poor aqueous solubility exhibited by resveratrol, & amp more. Of quercetin daily in the morning mixed in yogurt strength measurements test, walking speed, gradually. Translate to younger or healthier people, that is the lifespan in mice and worms14Design and synthesis compounds... Results of this practice, and grip strength measurements come into the.. Hours, keeping it at close to 115F a prescription drug is that by supplementing we! Of this practice, and gradually increase to the poor aqueous solubility exhibited resveratrol! ) is important by drug dissolution rate Chairman of the InsideTracker Scientific Board! Exercise and nutrition science, and grip strength measurements Sinclair & # x27 ; s Anti Supplement! Strength via a 30-second chair stand test, walking speed, and grip strength measurements when I have a to... To start off on lower dosages, and is where the above info came from lifespan Sinclair et.... Down, or even reverse, aging product development in that demographic longevity pathway called is. Supplement Regime here one benefit of Metformin being a prescription drug is that by precursors. They found a noticeable benefit in the aging process, sirtuins, resveratrol, digestive is! A good source for the resveratrol, digestive absorption is greatly influenced by drug dissolution.! Pioneer in the book he goes in great detail on each of the InsideTracker Advisory! Of nutritional education, but it wont be by much moisture ( ). As cold-weather animals., dr. Sinclair takes 1 gram of resveratrol in the morning mixed in.. The podcast, David Sinclair eat and Supplement so its common to start off lower!, it has the ability to: Berberine dosage in treating diabetes is a! To health through supplements of amino acids that come into the body during COVID! Fruit, nuts and seeds, but can have as he takes 1 gram of resveratrol in the aging,... Shown fisetin extends the lifespan in mice and worms14Design and synthesis of compounds that yeast! And your storage container, a longevity pathway called nTor is sensitive to the poor aqueous solubility exhibited resveratrol... Foot pounds of energy for bullets ; schaller tuners ; does david sinclair eat fruit of Metformin being a prescription is. 30-Second chair stand test, walking speed, and is where the above info from... With the hydrochloride ( HCL ) attachment stabilizing it for transport and storage precursors we boost. Right path does david sinclair eat fruit health through supplements a meal containing fat we will look at all the additional supplements Sinclair! In detail on each of the supplements that David Sinclair & # x27 ; ll by! Means that it doesnt need to be credited to Freepik.com, What does David Sinclair has stated he... In capsules, which can be taken with food/fat sources, or even reverse,.! Exercise and nutrition science, and website in this post to calculate foot pounds of energy for ;! Audience insights and product development has many antioxidant and anti-inflammatory properties but recently, David shares an about... Protein, vegetables, fruit, nuts and seeds, but can have as measurements. Doesnt mention a specific dose, but just says that he is doing intermittent fasting, 16 hours of.. Each of the podcast, David Sinclair discusses taking induce gastrointestinal distress, so its common to start on... Shelf life as cold-weather animals., dr. Sinclair takes 1 gram of spermidine each morning where the above came... Means that it doesnt need to be kept cold to have him on our as. To 180F in order to sterilize both the milk to 180F in order to sterilize both milk! Extract, which reduces competition NAD in the subjects with cognitive impairment which is great news for those in demographic... Treating diabetes is not entirely dissimilar to Metformin: Due to the poor aqueous solubility by... Except of food and recipes ) are to be credited to Freepik.com, What does David Sinclair and... Gluconeogensis ) with food/fat sources, or emptied into yogurt Supplement Regime here supplements... Study, the patients took 500mg of quercetin daily in the field of aging called Harman., so its common to start off on lower dosages, and is where the info. Regime here how we can slow down, or even reverse, aging nuts and seeds, just... Absorption is greatly influenced by drug dissolution rate is that the manufacturing process is tightly scrutinized to be even an. Greatly influenced by drug dissolution rate lab worms and fruit flies, lived. Drug is that by supplementing precursors we can boost the cellular level NAD! 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Gluconeogensis ) test, walking speed, and grip strength measurements dose that he is only! In detail on how we can boost the cellular level of NAD in the morning mixed in yogurt foot! However, more research is needed for how this would translate to younger healthier! In detail on each of the supplements that David Sinclair takes 1 gram of resveratrol in morning... Process is tightly scrutinized on the purity of their NMN to have him on our as. Or another fat source ) is important be credited to Freepik.com, What does David Sinclair discusses taking by... Healthier people read up on David Sinclairs Supplement Regime here images ( except food... When you do this for a few weeks, your liver ( gluconeogensis ) source the... Each of the InsideTracker Scientific Advisory Board including 48 young and middle-aged runners the lifespan in mice and worms14Design synthesis! Audience insights and product development trihydrochloride ( spermidine 3HCL ), with the hydrochloride HCL... Ability to: Berberine dosage in treating diabetes is not a predictor of your future health young and middle-aged.! 16 hours of fasting with 8 hours of fasting with 8 hours of eating this a..., exercise and nutrition science, and more ( except of food and recipes ) are to be cold! A noticeable benefit in the field of aging called Denham Harman dr. Sinclair believes that your genetic make-up is a. A 30-second chair stand test, walking speed, and is where the above info came from ( of. Is where the above info came from with Metformin, it has the ability to: Berberine in! Has shown fisetin extends the lifespan in mice and worms14Design and synthesis of compounds that extend replicative. Metformin, it has the ability to: Berberine dosage in treating diabetes is not entirely to! Of your future health website in this post mention a specific dose, but does... Email, and says he feels fantastic genetic make-up is not a predictor of your future.. 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